Aspects of a method and system for decoding single antenna interference cancellation (SAIC) and redundancy processing adaptation using frame process are provided. A receiver may decode video, voice, and/or speech bit sequences based on a first decoding algorithm that may utilize data redundancy and that may impose physical constraints. The receiver may also decode a bit sequence based on a second decoding algorithm that utilizes SAIC. The first and second decoding algorithms may be adapted to perform in parallel and a decoded received bit sequence may be selected based on a redundancy verification parameter. The first and second decoding algorithms may also be adapted to be performed sequentially where the subsequent decoding operation may be conditioned to the initial decoding operation. Moreover, either the first or the second decoding algorithm may be selected for decoding the received bit sequence. The selection may be based on noise and/or interference measurements.