A hybrid protection circuit may include a stress detection circuit, a clamp device, and an on-time adjustment circuit. The stress detection circuit may output a detection signal that may be activated when a positive ESD event or a positive EOS event occurs. The on-time adjustment circuit may receive a detection signal and output a clamping signal that may be in an active state until charges generated by a positive ESD event or a positive EOS event are discharged. The clamp device may discharge charges induced by an ESD event or an EOS event. Therefore, a hybrid protection circuit may protect the internal core from both an ESD event and an EOS event.