Invention Grant
US07807699B2 Dimeric pyrrolidine amide-containing small molecule apoptosis promoters
有权
含二聚吡咯烷酰胺的小分子凋亡启动子
- Patent Title: Dimeric pyrrolidine amide-containing small molecule apoptosis promoters
- Patent Title (中): 含二聚吡咯烷酰胺的小分子凋亡启动子
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Application No.: US11726602Application Date: 2007-03-21
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Publication No.: US07807699B2Publication Date: 2010-10-05
- Inventor: Gunnar J. Hanson , David Thomas , Nizal Chandrakumar , Susan Harran
- Applicant: Gunnar J. Hanson , David Thomas , Nizal Chandrakumar , Susan Harran
- Applicant Address: US TX Dallas
- Assignee: Joyant Pharmaceuticals, Inc.
- Current Assignee: Joyant Pharmaceuticals, Inc.
- Current Assignee Address: US TX Dallas
- Agent Richard Aron Osman
- Main IPC: A01N43/64
- IPC: A01N43/64
Abstract:
The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
Public/Granted literature
- US20080051389A1 Small molecule apoptosis promoters Public/Granted day:2008-02-28
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