Provided is an apparatus and method for canceling interference by a base station in a wireless mobile communication system. The method includes measuring a state of a channel with a mobile station, determining metric function values for channels that act as interference to the channel of the mobile station, selecting a predetermined number of interference channels in descending order of the metric function values, determining a weight vector for removing a signal transmitted over the interference channels, and applying the determined weight vector to a transmission signal and transmitting the weight vector applied signal.