Invention Grant
- Patent Title: Prostate cancer-related compositions, methods, and kits based on DNA macroarray proteomics platforms
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Application No.: US10140602Application Date: 2002-05-07
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Publication No.: US07790861B2Publication Date: 2010-09-07
- Inventor: Mark Stearns , Youji Hu , Min Wang
- Applicant: Mark Stearns , Youji Hu , Min Wang
- Applicant Address: US PA Philadelphia
- Assignee: Philadelphia Health and Education Corporation
- Current Assignee: Philadelphia Health and Education Corporation
- Current Assignee Address: US PA Philadelphia
- Agency: Drinker Biddle & Reath LLP
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K2/00 ; C07K4/00 ; C07K5/00 ; C07K17/00 ; C12P21/00 ; C12Q1/00 ; G01N33/00 ; G01N33/48 ; G01N33/53 ; G01N33/563 ; G01N33/567
Abstract:
The invention relates to novel nucleic acids encoding a mammalian PCADM-1 gene, and proteins encoded thereby, whose expression is increased in certain diseases, disorders, or conditions, including, but not limited to, prostate cancer. The invention further relates to methods of detecting and treating prostate cancer, comprising modulating or detecting PCADM-1 expression and/or production and activity of PCADM-1 polypeptide. Further, the invention relates to novel assays for the identification of DNA-binding proteins and the double-stranded oligonucleotide sequences that specifically bind with them. Finally, the invention relates to DNAZYMs or DNA enzymes which specifically bind PCADM-1 mRNA to inhibit PCADM-1 gene expression and thereby destroy tumor cells and tumor tissue.
Public/Granted literature
- US20030100033A1 Prostate cancer-related compositions, methods, and kits based on DNA macroarray proteomics platforms Public/Granted day:2003-05-29
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