Invention Grant
- Patent Title: Targeting and imaging tumor vasculature using conjugates that bind to aminophospholipids
- Patent Title (中): 使用结合氨磷脂的结合物靶向和成像肿瘤血管
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Application No.: US12371458Application Date: 2009-02-13
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Publication No.: US07790860B2Publication Date: 2010-09-07
- Inventor: Philip E. Thorpe , Sophia Ran , Rolf A. Brekken
- Applicant: Philip E. Thorpe , Sophia Ran , Rolf A. Brekken
- Applicant Address: US TX Austin
- Assignee: Board of Regents, The University of Texas System
- Current Assignee: Board of Regents, The University of Texas System
- Current Assignee Address: US TX Austin
- Agent Shelley P. M. Fussey
- Main IPC: A61K49/00
- IPC: A61K49/00 ; A61K49/04 ; A61K49/16 ; A61K51/10
Abstract:
Disclosed is the surprising discovery that aminophospholipids, such as phosphatidyserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor blood vessels. The present invention thus provides aminophospholipid-targeted diagnostic and therapeutic constructs for use in tumor intervention. Antibody-therapeutic agent conjugates and constructs that bind to aminophospholipids are particularly provided, as are methods of specifically delivering therapeutic agents, including toxins and coagulants, to the stably-expressed aminophospholipids of tumor blood vessels, thereby inducing thrombosis, necrosis and tumor regression.
Public/Granted literature
- US20090191121A1 Targeting and Imaging Tumor Vasculature Using Conjugates That Bind to Aminophospholipids Public/Granted day:2009-07-30
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