Invention Grant
US07790750B2 Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
有权
3-或4-取代的4-(氨基甲基) - 哌啶衍生物的双环苯甲酰胺
- Patent Title: Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
- Patent Title (中): 3-或4-取代的4-(氨基甲基) - 哌啶衍生物的双环苯甲酰胺
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Application No.: US11584732Application Date: 2006-10-20
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Publication No.: US07790750B2Publication Date: 2010-09-07
- Inventor: Jean-Paul René Marie André Bosmans , Michel Anna Jozef De Cleyn , Michel Surkyn
- Applicant: Jean-Paul René Marie André Bosmans , Michel Anna Jozef De Cleyn , Michel Surkyn
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica N.V.
- Current Assignee: Janssen Pharmaceutica N.V.
- Current Assignee Address: BE Beerse
- Agency: Woodcock Washburn, LLP
- Priority: EP97202180 19970711; EP98200624 19980227
- Main IPC: A61K31/445
- IPC: A61K31/445 ; C07D407/02

Abstract:
The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R1 and R2 taken together form a bivalent radical of formula wherein in said bivalent radicals one or two hydrogen atoms may be substituted with C1-6alkyl; R3 is hydrogen or halo; R4 is hydrogen or C1-6alkyl; R5 is hydrogen or C1-6alkyl; L is C3-6cycloalkyl, C5-6cycloalkanone, C2-6alkenyl, or L is a radical of formula -Alk-R6—, Alk-X—R7, -Alk-Y—C(═O)—R9, or -Alk-Y—C(═O)—NR11R12 wherein each Alk is C1-12alkanediyl; and R6 is hydrogen, cyano, C1-6alkylsulfonylamino, C3-6cycloalkyl, C5-6cycloalkanone, or a heterocyclic ringsystem; R7 is hydrogen, C1-6alkyl, hydroxyC1-6alkyl, C3-6cycloalkyl, or a heterocyclic ringsystem; X is O, S, SO2 or NR8; said R8 being hydrogen or C1-6alkyl; R9 is hydrogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxy or hydroxy; Y is NR10 or a direct bond; said R10 being hydrogen, or C1-6alkyl; R11 and R12 each independently are hydrogen, C1-6alkyl, C3-6cycloalkyl, or R11 and R12 combined with the nitrogen atom may form an optionally substituted pyrrolidinyl, piperidinyl, piperazinyl or 4-morpholinyl ring. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impairment of gastric emptying.
Public/Granted literature
- US20070037850A1 Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives Public/Granted day:2007-02-15
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