Invention Grant
- Patent Title: Cyclic peptide antifungal agents and process for preparation thereof
- Patent Title (中): 环肽类抗真菌剂及其制备方法
-
Application No.: US11078791Application Date: 2005-03-10
-
Publication No.: US07790744B2Publication Date: 2010-09-07
- Inventor: Frederick J. Burkhardt , Manuel Debono , Jeffrey S. Nissen , William Wilson Turner, Jr.
- Applicant: Frederick J. Burkhardt , Manuel Debono , Jeffrey S. Nissen , William Wilson Turner, Jr.
- Applicant Address: US IN Indianapolis
- Assignee: Eli Lilly and Company
- Current Assignee: Eli Lilly and Company
- Current Assignee Address: US IN Indianapolis
- Agent Jennifer Kispert; J. Michael Dixon
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/12
Abstract:
Provided are compounds of the formula (1): wherein R′ is hydrogen, methyl or NH2C(O)CH2—; R″ and R′″ are independently methyl or hydrogen; R adn Ry are independently hydroxy or hydrogen; R1 is hydroxy, hydrogen, or hydroxysulfonyloxy; R7 is hydroxy, hydrogen, hydroxysulfonyloxy or phosphonooxy; R2 is a novel acyl side chain. Also provided are novel formulations, methods of inhibiting fungal and parasitic activity, and a process for preparing dideoxy (R═H) forms of the compounds.
Public/Granted literature
- US20050181984A1 Cyclic peptide antifungal agents and process for preparation thereof Public/Granted day:2005-08-18
Information query
IPC分类:
