Invention Grant
US07790740B2 Imidazopyridine substituted tropane derivatives with CCR5 receptor antagonist activity for the treatment of HIV and inflammation
有权
具有CCR5受体拮抗剂活性的咪唑并吡啶取代的托烷衍生物用于治疗HIV和炎症
- Patent Title: Imidazopyridine substituted tropane derivatives with CCR5 receptor antagonist activity for the treatment of HIV and inflammation
- Patent Title (中): 具有CCR5受体拮抗剂活性的咪唑并吡啶取代的托烷衍生物用于治疗HIV和炎症
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Application No.: US11845500Application Date: 2007-08-27
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Publication No.: US07790740B2Publication Date: 2010-09-07
- Inventor: Paul Anthony Stupple
- Applicant: Paul Anthony Stupple
- Applicant Address: US NY New York
- Assignee: Pfizer Inc
- Current Assignee: Pfizer Inc
- Current Assignee Address: US NY New York
- Agent Jennifer Kispert; J. Michael Dixon
- Priority: GB0323236.0 20031003; GB0325020.6 20031027; GB0418566.6 20040819
- Main IPC: A61K31/44
- IPC: A61K31/44 ; C07D471/02
Abstract:
The present invention provides compounds of formula (I) wherein R1 and R2 are as defined hereinabove. The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors. Modulators of the CCR5 receptor may be useful in the treatment of various inflammatory diseases and conditions, and in the treatment of infection by HIV and genetically related retroviruses.
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