Invention Grant
- Patent Title: Methanocarba cycloalkyl nucleoside analogues
- Patent Title (中): 甲烷碳环环烷基核苷类似物
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Application No.: US11500860Application Date: 2006-08-08
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Publication No.: US07790735B2Publication Date: 2010-09-07
- Inventor: Kenneth A Jacobson , Victor E Marquez
- Applicant: Kenneth A Jacobson , Victor E Marquez
- Applicant Address: US MD Bethesda
- Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee Address: US MD Bethesda
- Agency: Leydig, Voit & Mayer, Ltd.
- Main IPC: C07D239/54
- IPC: C07D239/54 ; A61K31/513
Abstract:
The present invention provides novel nucleoside and nucleotide derivatives that are useful agonist or antagonists of P1 and P2 receptors. For example, the present invention provides a compound of formula A-M, wherein A is modified adenine or uracil and M is a constrained cycloalkyl group. The adenine or uracil is bonded to the constrained cycloalkyl group. The compounds of the present invention are useful in the treatment or prevention of various diseases including airway diseases (through A2B, A3, P2Y2 receptors), cancer (through A3, P2 receptors), cardiac arrhythmias (through A1 receptors), cardiac ischemia (through A1, A3 receptors), epilepsy (through A1, P2X receptors), and Huntington's Disease (through A2A receptors).
Public/Granted literature
- US20060270629A1 Methanocarba cycloalkyl nucleoside analogues Public/Granted day:2006-11-30
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