Invention Grant
- Patent Title: Immunostimulating agents
- Patent Title (中): 免疫刺激剂
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Application No.: US10557108Application Date: 2004-05-13
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Publication No.: US07790189B2Publication Date: 2010-09-07
- Inventor: Masami Mizu , Seiji Shinkai , Kazuo Sakurai , Kazuya Koumoto , Munenori Numata , Takahiro Matsumoto
- Applicant: Masami Mizu , Seiji Shinkai , Kazuo Sakurai , Kazuya Koumoto , Munenori Numata , Takahiro Matsumoto
- Applicant Address: JP Tokyo JP Saitama
- Assignee: Mitsui Sugar Co., Ltd.,Japan Science and Technology Agency
- Current Assignee: Mitsui Sugar Co., Ltd.,Japan Science and Technology Agency
- Current Assignee Address: JP Tokyo JP Saitama
- Agency: Fay Sharpe LLP
- Priority: JP2003-136876 20030515
- International Application: PCT/JP2004/006793 WO 20040513
- International Announcement: WO2004/100965 WO 20041125
- Main IPC: A61K45/00
- IPC: A61K45/00 ; A61K38/16 ; A61K31/70 ; A61K31/715 ; A01N43/04

Abstract:
Disclosed is a new type of immunostimulating agent including an immunostimulating oligonucleotide complexed with a carrier which is safe and has a high transfection effect. The carrier complexed with the immunostimulating oligonucleotide to form the immunostimulating agent is a polysaccharide having β-1,3-bonds (preferably β-1,3-glucan such as schizophyllan). A preferred example of the immunostimulating oligonucleotide is one containing an unmethylated CpG motif. The polysaccharide for use is preferably modified with nucleic acid-binding functional group and/or cell membrane-affinitive functional group.
Public/Granted literature
- US20080262210A1 Immunostimulating Agents Public/Granted day:2008-10-23
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