Invention Grant
- Patent Title: Live attenuated viral vaccines for Eastern Equine Encephalitis virus
- Patent Title (中): 东方马脑炎病毒减毒病毒疫苗
-
Application No.: US10853952Application Date: 2004-05-26
-
Publication No.: US07790181B2Publication Date: 2010-09-07
- Inventor: Peter L. Platteborze , Michael D. Parker
- Applicant: Peter L. Platteborze , Michael D. Parker
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary of the Army
- Current Assignee: The United States of America as represented by the Secretary of the Army
- Current Assignee Address: US DC Washington
- Agent Elizabeth Arwine
- Main IPC: A61K39/12
- IPC: A61K39/12 ; C12N7/04 ; C12N15/40
Abstract:
Live attenuated Eastern Equine Encephalitis (EEE) vaccines that outperform the PE-6 vaccine in mice aerosol challenged with >1,000×LD50. Candidates include four furin-cleavage deletion mutants and one E3 deletion mutant. Each vaccine provided protection in birds against antigenically distinct North and South American strains of EEE. The PE-6 vaccine does not provide protection against South American EEEs. Animals inoculated with each of the vaccines of the invention developed neutralizing antibodies to EEE.
Public/Granted literature
- US20040253271A1 Live attenuated viral vaccines for Eastern equine encephalitis virus Public/Granted day:2004-12-16
Information query
