A setup information generating device for a punch press which can generate setup information on replacement of a punch and a die with compatible tools, that is, replacement among punches and dies identified by the same tool number and used for processing for the same shape and the same size and which can also generate setup information according to processing know-how or the like. The device has a setup information generating device 48 for comparing a processing schedule with tool numbers in a mounted tool information storage device 45 to generate setup information. The device has a compatible tool registering device 38 for registering processing conditions such as material quality and board thickness and information on which of plural types of punches 81 and dies 82 identified by the same tool number are compatible as a punch 81 and a die 82 which meet the processing conditions are registered in accordance with inputs from an operation panel 46. In addition to performing the comparison of the tool numbers, the setup information generating device 48 checks the processing conditions contained in the processing schedule against the compatible tool registering device 38, and compares the obtained compatibility numbers of the compatible punch 81, and die 82 with the compatibility numbers stored in the mounted tool information storage device 45.