An embodiment of a method for use in performing interoperability testing between two network architectures includes forming multiple transaction signatures that each characterizes a communication transaction conducted over the two networks and analyzing each of the transaction signatures to determine if the transaction signature matches a previously classified pattern. The method may further include generating a report identifying each of the communication transactions and indicating that each of the communication transactions is classified with a classification associated with a previously classified pattern or are of unknown classification. Another method includes receiving a transaction signature composed of multiple transaction elements, and determining whether the received transaction signature corresponds to a previously identified transaction signature pattern. If the transaction signature does not correspond to a previously identified transaction signature pattern, a new transaction signature pattern is created, and classified as one of a plurality of classifications indicative of completion or failure of the communication transaction.