A method and apparatus for transmitting and receiving data by performing an iterative multi-user detection is provided. The apparatus includes: a receives a transmission signal and generates a received signal, the transmission signal being generated by modulating a single carrier signal via a modulation process, specialized for each user, in a wireless communication system; an interference canceled signal generator which generates an interference canceled signal by canceling a signal interference using a demodulated signal with respect to the received signal, the signal interference being caused by an other user; and a demodulated signal generator which generates the demodulated signal by demodulating the received signal via a demodulation process using the interference canceled signal, the demodulation process being specialized for each user, wherein the demodulated signal, which is generated by performing the generating of the interference canceled signal and the generating of the demodulated signal at least once, is adopted as a final demodulated signal.