Invention Grant
US07750192B2 Purification of Fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane) 失效
氟甲基1,1,1,3,3,3-六氟异丙基醚(七氟烷)的纯化

Purification of Fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane)
Abstract:
Crude sevoflurane product comprising unacceptably high levels of HFIP can be purified by combining the crude sevoflurane product with sufficient water to produce a multiphase mixture, fractionally distilling the multiphase mixture, removing sevoflurane from the distilling multiphase mixture as an azeotrope with water, and separating substantially pure sevoflurane from the azeotrope.
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