Invention Grant
- Patent Title: 1-substituted-3-β-D-glucopyranosylated nitrogenous hetero-cyclic compounds and medicines containing the same
- Patent Title (中): 1-取代-3-吡喃葡糖基氮杂环化合物和含有它们的药物
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Application No.: US11719201Application Date: 2005-11-17
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Publication No.: US07750145B2Publication Date: 2010-07-06
- Inventor: Shigeru Yonekubo , Nobuhiko Fushimi
- Applicant: Shigeru Yonekubo , Nobuhiko Fushimi
- Applicant Address: JP Nagano
- Assignee: Kissei Pharmaceutical Co., Ltd.
- Current Assignee: Kissei Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Nagano
- Agency: Sughrue Mion, PLLC
- Priority: JP2004-334165 20041118
- International Application: PCT/JP2005/021104 WO 20051117
- International Announcement: WO2006/054629 WO 20060526
- Main IPC: C07H7/06
- IPC: C07H7/06 ; A01N43/04 ; A61K31/70

Abstract:
A compound having an SGLT1 and/or SGLT2 inhibitory activity which is usable as an agent for the prevention or treatment of diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications, obesity, etc. It is a 1-substituted-3-(β-D-glycopyranosyl) nitrogen-containing heterocyclic compound represented by the general formula (I), a prodrug thereof, or a pharmaceutically acceptable salt thereof, or a hydrate or a solvate thereof; an SGLT inhibitor containing the same; a pharmaceutical composition containing the same and a combination pharmacy of them. In the formula, A represents an alkylene group or alkenylene group; B represents a single bond, —O—, —S— or —NH—; C represents an optionally substituted aryl or heteroaryl group; Q independently represents a carbon atom which a hydrogen atom or a substituent binds to, or a nitrogen atom.
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