Invention Grant
- Patent Title: Methods and compositions for enhancing the efficacy and specificity of RNA silencing
- Patent Title (中): 提高RNA沉默功效和特异性的方法和组合物
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Application No.: US10912440Application Date: 2004-08-04
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Publication No.: US07750144B2Publication Date: 2010-07-06
- Inventor: Phillip D. Zamore , György Hutvágner , Dianne Schwarz , Martin Simard
- Applicant: Phillip D. Zamore , György Hutvágner , Dianne Schwarz , Martin Simard
- Applicant Address: US MA Boston
- Assignee: University of Massachusetts
- Current Assignee: University of Massachusetts
- Current Assignee Address: US MA Boston
- Agency: Lahive & Cockfield, LLP
- Agent Debra J. Milasincic, Esq.; James H. Velema, Esq.
- Main IPC: C07H21/00
- IPC: C07H21/00 ; C07H21/02 ; C07H21/04 ; C12P19/34
Abstract:
The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
Public/Granted literature
- US20050186586A1 Methods and compositions for enhancing the efficacy and specificity of RNAi Public/Granted day:2005-08-25
Information query
