Invention Grant
- Patent Title: Compositions and methods for siRNA inhibition of angiogenesis
- Patent Title (中): siRNA抑制血管发生的组合物和方法
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Application No.: US11423006Application Date: 2006-06-08
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Publication No.: US07750143B2Publication Date: 2010-07-06
- Inventor: Michael J. Tolentino , Samuel Jotham Reich
- Applicant: Michael J. Tolentino , Samuel Jotham Reich
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Pepper Hamilton LLP
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04
Abstract:
RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
Public/Granted literature
- US20070003523A1 COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS Public/Granted day:2007-01-04
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