Invention Grant
- Patent Title: Vascular endothelial cell growth inhibitor, VEGI-192a
- Patent Title (中): 血管内皮细胞生长抑制因子VEGI-192a
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Application No.: US11999918Application Date: 2007-12-06
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Publication No.: US07750133B2Publication Date: 2010-07-06
- Inventor: Luyuan Li , Hongguang Pan
- Applicant: Luyuan Li , Hongguang Pan
- Applicant Address: US DC Washington
- Assignee: Georgetown University
- Current Assignee: Georgetown University
- Current Assignee Address: US DC Washington
- Agency: Morrison & Foerster LLP
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; C12N5/00 ; C12N5/07 ; C12N5/10 ; C12N15/00
Abstract:
This invention discloses two new VEGI isoforms named VEGI-192a and VEGI-192b consisting of 192 amino acid residues. These isoforms show endothelial cell-specific expression and share a C-terminal 151-residues segment with the previously described VEGI-174 and VEGI-251. Methods of using these isoforms of VEGI in diagnosing, screening agonist and antagonist of the isoforms, and treating various angiogenesis-related diseases are also disclosed.
Public/Granted literature
- US20090227014A1 Novel isoforms of vascular endothelial cell growth inhibitor Public/Granted day:2009-09-10
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