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US07750131B2 5′-modified bicyclic nucleic acid analogs 有权
5'-修饰的双环核酸类似物

5′-modified bicyclic nucleic acid analogs
Abstract:
The present invention provides 5′-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 5′-carbon. These bicyclic nucleoside analogs are useful for enhancing properties of oligomeric compounds including for example enhanced nuclease resistance.
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