Invention Grant
US07750045B2 Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system
有权
用于预防中枢神经系统急性和慢性损伤神经变性的化合物，组合物和方法
- Patent Title: Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system
- Patent Title (中): 用于预防中枢神经系统急性和慢性损伤神经变性的化合物，组合物和方法
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Application No.: US11205313Application Date: 2005-08-17
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Publication No.: US07750045B2Publication Date: 2010-07-06
- Inventor: Byoung Joo Gwag , Young Ae Lee , Bo Rum Ryu , Sung Hwa Yoon , Ho Sang Moon
- Applicant: Byoung Joo Gwag , Young Ae Lee , Bo Rum Ryu , Sung Hwa Yoon , Ho Sang Moon
- Applicant Address: KR
- Assignee: Neurotech Pharmaceuticals Co., Ltd.
- Current Assignee: Neurotech Pharmaceuticals Co., Ltd.
- Current Assignee Address: KR
- Agency: Seed IP Law Group PLLC
- Main IPC: A01N37/12
- IPC: A01N37/12 ; A01N37/44 ; A61K31/24 ; A61K31/245 ; A61K31/60
Abstract:
The present invention provides compositions and methods for prevention and prophylaxis of neurological diseases accompanied by neuronal death. The invention includes synthesis of 5-benzylamino salicylic acid (BAS) and its derivatives. BAS and its derivatives protect cortical neurons from toxic insults by N-methyl-D-aspartate, Zn2+, and reactive oxygen species. Thus, the present invention provides compositions and methods for treating stroke, traumatic brain and spinal cord injury, epilepsy, and neurodegenerative diseases that are accompanied by severe neuronal loss via excitotoxicity, Zn2+ neurotoxicity, and free radical neurotoxicity.
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