Invention Grant
- Patent Title: Method for the preparation of mycophenolate mofetil by enzyme tranesterification
- Patent Title (中): 通过酶促酯化反应制备霉酚酸酯的方法
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Application No.: US11661913Application Date: 2005-07-25
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Publication No.: US07727751B2Publication Date: 2010-06-01
- Inventor: Paride Grisenti , Paolo Prestileo
- Applicant: Paride Grisenti , Paolo Prestileo
- Applicant Address: IT Milan
- Assignee: Poli Industria Chimica SpA
- Current Assignee: Poli Industria Chimica SpA
- Current Assignee Address: IT Milan
- Agency: Hueschen and Sage
- Priority: ITMI2004A1703 20040903
- International Application: PCT/EP2005/053629 WO 20050725
- International Announcement: WO2006/024582 WO 20060309
- Main IPC: C12P7/62
- IPC: C12P7/62
Abstract:
The present invention relates to a process for the preparation of mycophenolate mofetil (MMF) in which an ester of mycophenolic acid (MPA) with a low-molecular-weight aliphatic alcohol is transesterified with N-(2-hydroxyethyl)morpholine in the presence of Candida antarctica lipase, and in which the MPA esterification reaction is carried out in the presence of Candida antarctica lipase using the corresponding alcohol as the solvent.
Public/Granted literature
- US20080085542A1 Method For The Preparation Of Mycophenolate Mofetil By Enzymatic Tranesterification Public/Granted day:2008-04-10
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