Invention Grant
- Patent Title: Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
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Application No.: US11016348Application Date: 2004-12-16
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Publication No.: US07709604B2Publication Date: 2010-05-04
- Inventor: Zhiwen Zhang , Lital Alfonta , Peter Schultz
- Applicant: Zhiwen Zhang , Lital Alfonta , Peter Schultz
- Applicant Address: US CA La Jolla
- Assignee: The Scripps Research Institute
- Current Assignee: The Scripps Research Institute
- Current Assignee Address: US CA La Jolla
- Agency: Quine Intellectual Property Law Group
- Agent Gary Baker
- Main IPC: C07K14/00
- IPC: C07K14/00 ; C12N9/00 ; C12N15/74 ; C07H21/02
Abstract:
This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.
Public/Granted literature
- US20050136513A1 Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells Public/Granted day:2005-06-23
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