Invention Grant
- Patent Title: P2X7 receptor antagonists and methods of use
- Patent Title (中): P2X7受体拮抗剂和使用方法
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Application No.: US11593377Application Date: 2006-11-06
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Publication No.: US07709469B2Publication Date: 2010-05-04
- Inventor: William A. Carroll , Alan S. Florjancic , Arturo Perez-Medrano , Sridhar Peddi
- Applicant: William A. Carroll , Alan S. Florjancic , Arturo Perez-Medrano , Sridhar Peddi
- Applicant Address: US IL Abbott Park
- Assignee: Abbott Laboratories
- Current Assignee: Abbott Laboratories
- Current Assignee Address: US IL Abbott Park
- Agency: Polsinelli Shughart PC
- Main IPC: A61K31/4439
- IPC: A61K31/4439 ; C07D403/14 ; C07D249/08
Abstract:
The invention is directed to compounds that are P2X7 antagonist and have the formula (I) or (II) or a pharmaceutically acceptable salt, prodrug, salt of a prodrug or a combination thereof, wherein R1, R2, and R3 are defined in the specification. The invention is also directed to a method of selectively inhibiting P2X7 activity comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound of formula (III), (IV) or (V) wherein R6, R7, R8, R9, R10, and R11 are defined in the specification.
Public/Granted literature
- US20070105842A1 P2X7 receptor antagonists and methods of use Public/Granted day:2007-05-10
Information query
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