An active body ventilation system which is dynamically responsive to vehicle status parameters, including for example the door open/closed status and the HVAC system status. An active ventilation unit is attached with a body wall which includes a portal housing defining a portal, a portal cover and a portal cover actuator for selectively adjusting the portal cover to thereby increase or decrease the unobstructed size of the opening of the portal. The active ventilation unit is interfaced electronically to various sensors of the motor vehicle, in which programming of an electronic control module determines optimum positioning of the portal covering via selective actuation of the portal cover actuator.