Invention Grant
- Patent Title: Di-ester prodrugs of camptothecin, process for their preparation and their therapeutical applications
- Patent Title (中): 喜树碱的二酯前药，其制备方法及其治疗应用
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Application No.: US10583803Application Date: 2004-12-23
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Publication No.: US07700612B2Publication Date: 2010-04-20
- Inventor: Patrick Soon-Shiong , Neil P. Desai , Chunlin Tao , Cheng Zhi Yu
- Applicant: Patrick Soon-Shiong , Neil P. Desai , Chunlin Tao , Cheng Zhi Yu
- Applicant Address: US CA Los Angeles
- Assignee: Abraxis BioScience, LLC
- Current Assignee: Abraxis BioScience, LLC
- Current Assignee Address: US CA Los Angeles
- Agency: Leydig, Voit & Mayer, Ltd.
- International Application: PCT/US2004/043719 WO 20041223
- International Announcement: WO2005/062985 WO 20050714
- Main IPC: A61K31/4745
- IPC: A61K31/4745 ; C07D491/22
Abstract:
The present invention is related to 10,20-di-O ester derivatives of camptothecin and pharmaceutical formulations thereof. The compounds and pharmaceutical formulations of the present invention possess increased biological life span and bioavailability and reduced toxicity, while maintaining anti-cancer activity.
Public/Granted literature
- US20070161668A1 Di-ester prodrugs of camptothecin, process for their preparation and their therapeutical applications Public/Granted day:2007-07-12
Information query
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