Invention Grant
- Patent Title: Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof
- Patent Title (中): 氨基醇衍生物,含有它们的药物组合物及其用途
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Application No.: US11936680Application Date: 2007-11-07
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Publication No.: US07674938B2Publication Date: 2010-03-09
- Inventor: Junichi Kobayashi , Tetsuya Nakamura , Ritsu Suzuki , Hideyuki Muranaka , Tomonaga Ozawa , Yuichiro Kai , Takehiro Ishikawa , Tatsuhiro Kondo , Tetsuro Tamai , Satoshi Akahane
- Applicant: Junichi Kobayashi , Tetsuya Nakamura , Ritsu Suzuki , Hideyuki Muranaka , Tomonaga Ozawa , Yuichiro Kai , Takehiro Ishikawa , Tatsuhiro Kondo , Tetsuro Tamai , Satoshi Akahane
- Applicant Address: JP Nagano
- Assignee: Kissei Pharmaceutical Co., Ltd.
- Current Assignee: Kissei Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Nagano
- Agency: Sughrue Mion, PLLC
- Priority: JP2003-035847 20030214; JP2003-041931 20030220
- Main IPC: C07C217/14
- IPC: C07C217/14 ; C07C217/20 ; C07D307/79 ; A61K31/195 ; A61P1/16 ; A61P3/04

Abstract:
The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen or lower alkyl; R3, R4, R5 and R6 are each hydrogen, halogen, lower alkyl or lower alkoxy; R7 and R8 are each hydrogen, halogen, lower alkyl, halo-lower alkyl, lower alkoxy, cycloalkyl, aryl, heteroaryl, cyano, a hydroxyl group, lower acyl, carboxy or the like; R9 is —C(O)—R10, -A1-C(O)—R10, —O-A2-C(O)—R10 or a tetrazol-5-yl group, which exhibit potent and selective β3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.
Public/Granted literature
- US20080249177A1 AMINO ALCOHOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND USE THEREOF Public/Granted day:2008-10-09
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