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Invention Grant
US07674909B2 Tetrahydroquinoline derivatives and their use as FSH receptor modulators 有权
四氢喹啉衍生物及其作为FSH受体调节剂的用途

Tetrahydroquinoline derivatives and their use as FSH receptor modulators
Abstract:
The present invention relates to tetrahydroquinoline derivatives having general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are H, Me; R3 is (2-6C)heterocycloalkyl(1-4C)alkyl, (2-5C)heteroaryl(1-4C)alkyl, (6C)aryl (1-4C)alkyl, (1-4C)(di)alkylaminocarbonylamino(2-4C)alkyl, (2-6C) heterocycloalkylcarbonylamino(2-4C)alkyl, R5-(2-4C)alkyl or R5-carbonyl(1-4C)alkyl; R4 is (2-5C)heteroaryl, (6C)aryl, (3-8C)cycloalkyl, (2-6C)heterocycloalkyl or (1-6C) alkyl and R5 is (di)(1-4C)alkylamino, (1-4C)alkoxy, amino, hydroxy, (6C)arylamino, (di)(3-4C)alkenylamino, (2-5C)heteroaryl(1-4C)alkylamino, (6C)aryl(1-4C) alkylamino, (di)[(1-4C)alkoxy(2-4C)alkyl]amino, (di)[(1-4C)alkylamino(2-4C) alkyl]amino, (di)[amino(2-4C)alkyl]amino or (di)[hydroxy(2-4C)alkyl]amino. The present invention also relates to pharmaceutical compositions comprising said derivatives and the use of these derivatives to regulate fertility.
Abstract(Chinese):

本发明涉及具有通式（I）的四氢喹啉衍生物或其药学上可接受的盐，其中R1和R2是H，Me; R3是（2-6C）杂环烷基（1-4C）烷基，（2-5C）杂芳基（1-4C）烷基，（6C）芳基（1-4C）烷基，（1-4C）（二）烷基氨基羰基氨基 -4C）烷基，（2-6C）杂环烷基羰基氨基（2-4C）烷基，R5-（2-4C）烷基或R5-羰基（1-4C）烷基; R4为（2-5C）杂芳基，（6C）芳基，（3-8C）环烷基，（2-6C）杂环烷基或（1-6C）烷基，R5为（二）（1-4C）烷基氨基，（1- （C 6）芳基氨基，（二）（3-4C）链烯基氨基，（2-5C）杂芳基（1-4C）烷基氨基，（6C）芳基（1-4C）烷基氨基，（二） 氨基，（二）[氨基（2-4C）烷基]氨基或（（C 1 -C 4）烷基]氨基或（ 二）[羟基（2-4C）烷基]氨基。 本发明还涉及包含所述衍生物的药物组合物和这些衍生物用于调节生育力的用途。

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