Invention Grant
US07674839B2 Methods for the production of polymer carrier materials based on carbon hydrate-bis(meth)acryl-amides
失效
基于碳水化合物 - 双(甲基)丙烯酰胺的聚合物载体材料的生产方法
- Patent Title: Methods for the production of polymer carrier materials based on carbon hydrate-bis(meth)acryl-amides
- Patent Title (中): 基于碳水化合物 - 双(甲基)丙烯酰胺的聚合物载体材料的生产方法
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Application No.: US11631236Application Date: 2005-06-24
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Publication No.: US07674839B2Publication Date: 2010-03-09
- Inventor: Thomas Verdianz , Heinrich Gruber , Simone Knaus , Alexander Poschalko
- Applicant: Thomas Verdianz , Heinrich Gruber , Simone Knaus , Alexander Poschalko
- Applicant Address: AT Vienna
- Assignee: Technische Universitat
- Current Assignee: Technische Universitat
- Current Assignee Address: AT Vienna
- Agency: Drinker Biddle & Reath LLP
- Agent Daniel A. Monaco
- Priority: ATA1100/2004 20040629
- International Application: PCT/AT2005/000230 WO 20050624
- International Announcement: WO2006/000008 WO 20060105
- Main IPC: C08F236/20
- IPC: C08F236/20 ; C07H15/04 ; C07H15/12 ; C08J9/00 ; C08F251/00

Abstract:
The invention relates to methods for the production of polymer carrier materials for solid phase synthesis, particularly for peptide synthesis. (Meth)acrylamide derivatives based on carbon hydrates, which can also contain other protective groups, are polymerized by means of suspension polymerization in an aqueous phase, optionally with the addition of pore-forming additives, and subsequently the protective groups are fully or partially cleaved. It is thus possible to obtain polymer carriers whose morphology (particle size, porosity), degree of cross-linking and swelling capability in aqueous and organic media can be adjusted in a targeted manner and whose reactive groups offer multiple opportunities for the immobilization of anchor groups and protective groups. The hydroxyl groups of the polymer carrier can be activated according to usual methods of solid phase synthesis.
Public/Granted literature
- US20080300383A1 Methods for the Production of Polymer Carrier Materials Based on Carbon Hydrate-Bis(Meth)Acryl-Amides Public/Granted day:2008-12-04
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