Invention Grant
US07674818B2 Aryl, aryloxy, alkyloxy substituted 1H-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
失效
芳基，芳氧基，烷氧基取代的1H-吲哚-3-基乙醛酸衍生物作为纤溶酶原激活物抑制剂-1（PAI-1）的抑制剂
- Patent Title: Aryl, aryloxy, alkyloxy substituted 1H-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
- Patent Title (中): 芳基，芳氧基，烷氧基取代的1H-吲哚-3-基乙醛酸衍生物作为纤溶酶原激活物抑制剂-1（PAI-1）的抑制剂
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Application No.: US11827579Application Date: 2007-07-11
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Publication No.: US07674818B2Publication Date: 2010-03-09
- Inventor: Lee Dalton Jennings , Hassan Mahmoud Elokdah , Geraldine Ruth McFarlane
- Applicant: Lee Dalton Jennings , Hassan Mahmoud Elokdah , Geraldine Ruth McFarlane
- Applicant Address: US NJ Madison
- Assignee: Wyeth LLC
- Current Assignee: Wyeth LLC
- Current Assignee Address: US NJ Madison
- Agent Mabel Ng; Scott Larsen; Michael Straher
- Main IPC: A61K31/404
- IPC: A61K31/404 ; C07D209/04
Abstract:
Compounds of formula I are provided: wherein: R1, R2, and R3, are as defined herein, as well as pharmaceutical composition and methods using the compounds as inhibitors of plasminogen activator inhibitor (PAI-1) and as therapeutic composition for treating conditions resulting from fibrinolytic disorders, such as deep vein thrombosis, coronary heart disease and pulmonary fibrosis.
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