Invention Grant
- Patent Title: Amidines and derivatives thereof and pharmaceutical compositions containing them
- Patent Title (中): 脒及其衍生物和含有它们的药物组合物
-
Application No.: US10568760Application Date: 2004-09-16
-
Publication No.: US07674806B2Publication Date: 2010-03-09
- Inventor: Marcello Allegretti , Maria Candida Cesta , Giuseppe Nano , Riccardo Bertini , Cinzia Bizzarri , Francesco Colotta
- Applicant: Marcello Allegretti , Maria Candida Cesta , Giuseppe Nano , Riccardo Bertini , Cinzia Bizzarri , Francesco Colotta
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: EP03103557 20030925
- International Application: PCT/EP2004/052201 WO 20040916
- International Announcement: WO2005/028425 WO 20050331
- Main IPC: C07D417/02
- IPC: C07D417/02 ; C07D413/02 ; A61K31/553 ; A61K31/541 ; A61K31/5377
Abstract:
Amidines and derivatives thereof of formula (I) are described. The process for their preparation and pharmaceutical compositions thereof are also described. The amidines of the invention are useful in the inhibition of chemotaxis of neutrophils induced by IL-8. The compounds of the invention are used in the treatement of psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.
Public/Granted literature
- US20070155717A1 Amidines and derivatives thereof and pharmaceutical compositions containing them Public/Granted day:2007-07-05
Information query
