Invention Grant
US07674797B2 2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity for the treatment of asthma and other inflammatory or immunological disorders
有权
具有CCR3拮抗活性的2-苯氧基和2-苯基磺酰胺衍生物，用于治疗哮喘和其他炎症或免疫疾病
- Patent Title: 2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity for the treatment of asthma and other inflammatory or immunological disorders
- Patent Title (中): 具有CCR3拮抗活性的2-苯氧基和2-苯基磺酰胺衍生物，用于治疗哮喘和其他炎症或免疫疾病
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Application No.: US10550482Application Date: 2004-03-11
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Publication No.: US07674797B2Publication Date: 2010-03-09
- Inventor: Yingfu Li , Kevin Bacon , Hiromi Sugimoto , Keiko Fukushima , Kentaro Hashimoto , Makiko Marumo , Toshiya Moriwaki , Noriko Nunami , Naoki Tsuno , Klaus Urbahns , Nagahiro Yoshida
- Applicant: Yingfu Li , Kevin Bacon , Hiromi Sugimoto , Keiko Fukushima , Kentaro Hashimoto , Makiko Marumo , Toshiya Moriwaki , Noriko Nunami , Naoki Tsuno , Klaus Urbahns , Nagahiro Yoshida
- Applicant Address: US CA San Diego
- Assignee: Axikin Pharmaceuticals, Inc.
- Current Assignee: Axikin Pharmaceuticals, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Jones Day
- Priority: EP03006293 20030324
- International Application: PCT/EP2004/002496 WO 20040311
- International Announcement: WO2004/084898 WO 20041007
- Main IPC: A01N43/42
- IPC: A01N43/42 ; A61K31/496 ; C07D221/18 ; C07D221/22
Abstract:
The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders. In said formula, X represents O or S; R4 represents formulae (a), (b), (c), (d), (e), (f), (g), (h), (i) or (j), the other substituents are as defined in claim 1.
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