Invention Grant
US07674767B2 Nanoparticle compositions of water-soluble drugs for oral administration and preparation methods thereof
有权
用于口服给药的水溶性药物的纳米颗粒组合物及其制备方法
- Patent Title: Nanoparticle compositions of water-soluble drugs for oral administration and preparation methods thereof
- Patent Title (中): 用于口服给药的水溶性药物的纳米颗粒组合物及其制备方法
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Application No.: US10584449Application Date: 2004-12-24
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Publication No.: US07674767B2Publication Date: 2010-03-09
- Inventor: Chaul Min Pai , Mi Hong Min , Jun Seok Hwang , Kyung Mi Cho
- Applicant: Chaul Min Pai , Mi Hong Min , Jun Seok Hwang , Kyung Mi Cho
- Applicant Address: KR Seoul
- Assignee: Samyang Corporation
- Current Assignee: Samyang Corporation
- Current Assignee Address: KR Seoul
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: KR10-2003-0096641 20031224
- International Application: PCT/KR2004/003448 WO 20041224
- International Announcement: WO2005/061004 WO 20050707
- Main IPC: A61K38/28
- IPC: A61K38/28 ; A61K47/06 ; C09D105/04
Abstract:
The present invention relates to an orally administrable composition containing nanoparticles with the particle size of 500 nm or less, comprising 0.1-30 weight % of a complex of a water-soluble drug and a counter-ion substance in which the charged water-soluble drug is bonded with the counter-ion substance, 0.5-80 weight % of a lipid, 0.5-80 weight % of a polymer, and 1-80 weight % of an emulsifier, wherein the weight ratio of said lipid and said polymer is in the range of 1:0.05-3, and a preparation method thereof. The composition of the present invention has high gastrointestinal absorption rate upon oral administration, and has high drug entrapping rate in the nanoparticle, and is also stable against lipases.
Public/Granted literature
- US20070154559A1 Nanoparticle compositions of water-soluble drugs for oral administration and preparation methods thereof Public/Granted day:2007-07-05
Information query
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