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US07670800B2 Process for the purification of riboflavin 有权
核黄素纯化方法

  • Patent Title: Process for the purification of riboflavin
  • Patent Title (中): 核黄素纯化方法
  • Application No.: US10565443
    Application Date: 2004-07-20
  • Publication No.: US07670800B2
    Publication Date: 2010-03-02
  • Inventor: Arnold Gloor
  • Applicant: Arnold Gloor
  • Applicant Address: NL Te Heerlen
  • Assignee: DSM IP Assets B.V.
  • Current Assignee: DSM IP Assets B.V.
  • Current Assignee Address: NL Te Heerlen
  • Agency: Hoxie & Associates LLC
  • Priority: EP03016512 20030722
  • International Application: PCT/EP2004/008097 WO 20040720
  • International Announcement: WO2005/014594 WO 20050217
  • Main IPC: C12P25/00
  • IPC: C12P25/00
Process for the purification of riboflavin
Abstract:
The invention relates to a process for the purification of riboflavin comprising the steps of (a) precipitating a first crystalline form of riboflavin, (b) isolating the first crystalline form of riboflavin, (c) transforming the first crystalline form of riboflavin into a second crystalline form of riboflavin under conditions that decompose diluted DNA, and (d) isolating the second crystalline form of riboflavin, provided that at ambient temperature the first crystalline form of riboflavin is thermodynamically less stable than the second crystalline form of riboflavin.
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