A sealing arrangement which is designed for a cylinder-piston arrangement of a reciprocating piston vacuum pump for sealing a gap between a cylinder wall and a piston displaceable in the cylinder, includes at least one L-shaped annular seal having one of its leg secured on the piston for providing a static sealing, and its another free leg adjoining the cylinder wall for providing a dynamic sealing, and an annular guide member arranged on the piston between the piston and the cylinder on a side of the seal remote from a compression chamber of the pump.