Invention Grant
- Patent Title: Process of making crystalline Type II aripiprazole
- Patent Title (中): 制备结晶II型阿立哌唑的方法
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Application No.: US11377398Application Date: 2006-03-17
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Publication No.: US07655798B2Publication Date: 2010-02-02
- Inventor: Gerrit J. B. Ettema , Raymond J. H. Westheim , Faysal Kalmoua
- Applicant: Gerrit J. B. Ettema , Raymond J. H. Westheim , Faysal Kalmoua
- Applicant Address: NL Nijmegen
- Assignee: Synthon BV
- Current Assignee: Synthon BV
- Current Assignee Address: NL Nijmegen
- Agent Mark R. Buscher
- Main IPC: C07D401/12
- IPC: C07D401/12 ; C07D413/12
Abstract:
Crystalline aripiprazole Type II can be formed without solid state heat treatment. Instead a liquid is used such as in crystallizing from a solvent, especially 2-propanol, dimethyl sulfoxide, or a combination thereof with ethyl acetate, or in a solvent mediated solid-solid transformation, typically in ethyl acetate.
Public/Granted literature
- US20060258673A1 Process of making crystalline Type II aripiprazole Public/Granted day:2006-11-16
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