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Invention Grant
US07655795B2 Process for preparing pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases 失效
制备核苷磷酸酶和核苷酸的吡咯并[3,2-d]嘧啶抑制剂的方法

Process for preparing pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
Abstract:
The present invention relates to a new process for the preparation of compounds of general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine nucleosidases (MTAN) and/or nucleoside hydrolases (NH). The present invention relates to a new process for the preparation of compounds of general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine nucleosidases (MTAN) and/or nucleoside hydrolases (NH).
Abstract(Chinese):

本发明涉及制备嘌呤核苷磷酸化酶（PNP），嘌呤磷酸核糖转移酶（PPRT），5'-甲硫基腺苷磷酸化酶（MTAP），5'-甲硫基腺苷核苷酸酶抑制剂的通式（I）化合物的新方法 （MTAN）和/或核苷水解酶（NH）。 本发明涉及制备嘌呤核苷磷酸化酶（PNP），嘌呤磷酸核糖转移酶（PPRT），5'-甲硫基腺苷磷酸化酶（MTAP），5'-甲硫基腺苷核苷酸酶抑制剂的通式（I）化合物的新方法 （MTAN）和/或核苷水解酶（NH）。

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