Invention Grant
- Patent Title: Tetrahydrobenzfluorene derivatives
- Patent Title (中): 四氢苯并芴衍生物
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Application No.: US11924507Application Date: 2007-10-25
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Publication No.: US07655653B2Publication Date: 2010-02-02
- Inventor: Hubert Jan Jozef Loozens
- Applicant: Hubert Jan Jozef Loozens
- Applicant Address: NL Oss
- Assignee: N.V. Organon
- Current Assignee: N.V. Organon
- Current Assignee Address: NL Oss
- Agent Susan Hess
- Priority: EP01205206 20011221
- Main IPC: A61K31/5375
- IPC: A61K31/5375 ; A61K31/495 ; C07D265/30 ; C07D241/04
Abstract:
A compound having the formula I wherein the O—(CH2)n—N(R1,R2) substituent on the phenyl ring can be in meta or para position; n is 2-4 Re and ′Re are OH, optionally independently etherified or esterified; R1 and R2 are independently (1C-4C)alkyl, (2C-4C)alkenyl, hydroxy(2C-4C)alkyl, (1C-3C)alkoxy(2C-4C)alkyl, aryl or aryl(1C-2C)alkyl; or R1 and R2 together with the nitrogen form an aromatic or non-aromatic heterocyclic ring structure, optionally mono- or poly-substituted with (1C-4C)alkyl, (2C-4C)alkenyl, hydroxy(1C-2C)alkyl, (1C-2C)alkoxy(1C-3C)alkyl or aryl. These compounds can be used for estrogen receptor β selective medical treatments.
Public/Granted literature
- US20080058361A1 TETRAHYDROBENZFLUORENE DERIVATIVES Public/Granted day:2008-03-06
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