Invention Grant
- Patent Title: Inhibitors of Akt activity
- Patent Title (中): Akt活性抑制剂
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Application No.: US11547367Application Date: 2005-04-05
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Publication No.: US07655649B2Publication Date: 2010-02-02
- Inventor: Mark T. Bilodeau , Peter C. Chua , Nicholas D. P. Cosford , Jacob M. Hoffman , Johnny Yasuo Nagasawa
- Applicant: Mark T. Bilodeau , Peter C. Chua , Nicholas D. P. Cosford , Jacob M. Hoffman , Johnny Yasuo Nagasawa
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Matthew A. Leff; David A. Muthard
- International Application: PCT/US2005/011687 WO 20050405
- International Announcement: WO2005/100344 WO 20051027
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D403/10 ; C07D403/14 ; C07D405/14 ; C07D409/14 ; C07D498/04 ; C07D413/14 ; C07D417/14 ; C07D279/12 ; C07D295/00 ; C07D237/08 ; C07D237/10 ; C07D401/10 ; A61K31/501 ; A61K31/506 ; A61K31/5377 ; A61K31/541 ; C07D239/24 ; C07D239/28 ; C07D265/16 ; C07D487/04 ; C07D317/12 ; C07F5/04 ; A61P35/00
Abstract:
The present invention is directed to compounds which contain substituted pyridazines and pyrimidines moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
Public/Granted literature
- US20080280889A1 Inhibitors of Akt Activity Public/Granted day:2008-11-13
Information query
