Invention Grant
US07655461B2 Therapeutic and diagnostic cloned MHC-unrestricted receptor specific for the MUC1 tumor associated antigen
有权
针对MUC1肿瘤相关抗原特异性的克隆MHC非受限受体的治疗和诊断受体
- Patent Title: Therapeutic and diagnostic cloned MHC-unrestricted receptor specific for the MUC1 tumor associated antigen
- Patent Title (中): 针对MUC1肿瘤相关抗原特异性的克隆MHC非受限受体的治疗和诊断受体
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Application No.: US11295767Application Date: 2005-12-07
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Publication No.: US07655461B2Publication Date: 2010-02-02
- Inventor: Olivera J. Finn , Nehad M. Alajez , Jan Schmielau , Mark D. Alter
- Applicant: Olivera J. Finn , Nehad M. Alajez , Jan Schmielau , Mark D. Alter
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsbugh — Of the Commonwealth System of Higher Education
- Current Assignee: University of Pittsbugh — Of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Leydig, Voit & Mayer, Ltd.
- Main IPC: C12N5/06
- IPC: C12N5/06
Abstract:
The invention provides an isolated nucleic acid encoding a receptor, other than an immunoglobulin, wherein the receptor binds to a MUC1 tumor antigen independently of an major histocompatibility complex (MHC). The invention provides a method of activating a signaling pathway and/or killing a cancer cell using a receptor that is similar to or is a T cell receptor.
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