The present invention relates to an air cleaning and filtering system, comprising an air intake filtering part and an air outlet filtering part, wherein the air intake filtering part further comprises filtering devices which connect with the air inlet and the air outlet of the air intake filtering part, wherein the air intake filtering part and the air outlet filtering part further comprise sterilizing units. The air cleaning and filtering system of the present invention can provide filtering and sterilization to the incoming and outgoing air of a room to purify and circulate the indoor air and prevent the backflow of the infected air, thus preventing disease spreading through air flow. The air cleaning and filtering system of the present invention can be widely used in hospital, mobile treatment room, clinic, hotel, theatre, office, toilet, public vehicles and home, etc.