A signal transmission wire with audio interface and USB interface, the wire is a four-core connection wire, one end of which is connected to a USB interface, the other end of which is connected to a dual-track audio interface; the four-core signal connection wire is further provided with a winder, the winder is a box, and a bobbin for intertwining the four-core connection wire is pivotally jointed in its cavity; two opening holes are set on the surface of the winder; the double ends of the four-core connection wire pass through the two opening holes respectively; the wire of the four-core connection wire is winded on the bobbin.