Invention Grant
- Patent Title: Cyclic ureas used as inhibitors of metalloproteases
- Patent Title (中): 循环脲用作金属蛋白酶抑制剂
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Application No.: US11763618Application Date: 2007-06-15
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Publication No.: US07652143B2Publication Date: 2010-01-26
- Inventor: Andreas Lindenschmidt , Holger Wagner , Jochen Beninga , Sven Grueneberg , Klaus-ulrich Weithmann
- Applicant: Andreas Lindenschmidt , Holger Wagner , Jochen Beninga , Sven Grueneberg , Klaus-ulrich Weithmann
- Applicant Address: DE Frankfurt am Main
- Assignee: sanofi-aventis Deutschland GmbH
- Current Assignee: sanofi-aventis Deutschland GmbH
- Current Assignee Address: DE Frankfurt am Main
- Agent James W. Bolcsak
- Priority: DE102004060229 20041215
- Main IPC: C07D401/00
- IPC: C07D401/00 ; C07D233/00 ; A61K31/17
Abstract:
The present invention relates to a novel compound of the formula I: and/or all stereoisomeric forms of the compound of the formula I and/or mixtures of these forms in any ratio, and/or a physiologically tolerated salt of the compound of the formula I, in which R1 to R5 and V1, V2 have the meanings stated in the claims and specification. The inventive compounds are suitable as inhibitors of metalloproteases, especially of ADAMTS proteases and TNF-α converting enzyme (TACE), and for the treatment of disorders such as but not limited to osteoarthrosis and rheumatoid arthritis.
Public/Granted literature
- US20080096918A1 NOVEL CYCLIC UREAS USED AS INHIBITORS OF METALLOPROTEASES Public/Granted day:2008-04-24
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