Invention Grant
US07652012B2 2-(R)-(4-fluoro-2-methyl-phenyl)-4-(S)-((8aS)-6-oxo-hexahydro-pyrrolo[1,2-a]-pyrazin-2-yl)-piperidine-1-carboxylic acid [1-(R)-3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide maleate and pharmaceutical compositions thereof
有权
2-（R） - （4-氟-2-甲基 - 苯基）-4-（S） - （（8aS）-6-氧代 - 六氢 - 吡咯并[1,2-a] - 吡嗪-2-基） - 哌啶-1-羧酸[1-（R）-3,5-双 - 三氟甲基 - 苯基） - 乙基] - 甲基酰胺马来酸盐及其药物组合物
![2-(R)-(4-fluoro-2-methyl-phenyl)-4-(S)-((8aS)-6-oxo-hexahydro-pyrrolo[1,2-a]-pyrazin-2-yl)-piperidine-1-carboxylic acid [1-(R)-3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide maleate and pharmaceutical compositions thereof](/docs/US/2010-01-26/US07652012B2/abs.jpg.600x600.jpg)
- Patent Title: 2-(R)-(4-fluoro-2-methyl-phenyl)-4-(S)-((8aS)-6-oxo-hexahydro-pyrrolo[1,2-a]-pyrazin-2-yl)-piperidine-1-carboxylic acid [1-(R)-3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide maleate and pharmaceutical compositions thereof
- Patent Title (中): 2-（R） - （4-氟-2-甲基 - 苯基）-4-（S） - （（8aS）-6-氧代 - 六氢 - 吡咯并[1,2-a] - 吡嗪-2-基） - 哌啶-1-羧酸[1-（R）-3,5-双 - 三氟甲基 - 苯基） - 乙基] - 甲基酰胺马来酸盐及其药物组合物
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Application No.: US11608853Application Date: 2006-12-11
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Publication No.: US07652012B2Publication Date: 2010-01-26
- Inventor: Giuseppe Alvaro , Romano Di Fabio , Maria Elvira Tranquillini , Simone Spada
- Applicant: Giuseppe Alvaro , Romano Di Fabio , Maria Elvira Tranquillini , Simone Spada
- Applicant Address: GB Middlesex
- Assignee: Glaxo Group Limited
- Current Assignee: Glaxo Group Limited
- Current Assignee Address: GB Middlesex
- Agent J. Scott Young
- Priority: GB0203020.3 20020208
- Main IPC: A61K31/497
- IPC: A61K31/497
![2-(R)-(4-fluoro-2-methyl-phenyl)-4-(S)-((8aS)-6-oxo-hexahydro-pyrrolo[1,2-a]-pyrazin-2-yl)-piperidine-1-carboxylic acid [1-(R)-3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide maleate and pharmaceutical compositions thereof](/abs-image/US/2010/01/26/US07652012B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to piperidine derivatives of formula (I) specifically 2-(R)-(4-Fluoro-2-methyl-phenyl)-4-(S)-((8aS)-6-oxo-hexahydro-pyrrolo[1,2-a]-pyrazin-2-yl)-piperidine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide maleate and pharmaceutical compositions thereof, useful in the treatment of conditions mediated by tachykinins.
Public/Granted literature
- US20070099914A1 Piperidine Derivatives Public/Granted day:2007-05-03
Information query
IPC分类:
