Methods and formulations for the treatment of malignancies. Assessment of the incidence and scope of MC in control and cancer populations provides for the development of cellular therapy approaches to hematologic malignancies that are expected to be well tolerated immunologically. Studies will confirm that parous females who display MC are able to tolerate donor cells from their male offspring immunologically. Studies will explore the use of MC offspring donor cells in cellular therapy for the treatment of hematologic and other malignancies.