Invention Grant
- Patent Title: Indole derivatives as CFTR modulators
- Patent Title (中): 吲哚衍生物作为CFTR调节剂
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Application No.: US11975297Application Date: 2007-10-18
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Publication No.: US07645789B2Publication Date: 2010-01-12
- Inventor: Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Fredrick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Djamel Numa
- Applicant: Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Fredrick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Djamel Numa
- Applicant Address: US MA Cambridge
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Cambridge
- Agency: Honigman Miller Schwartz and Cohn LLP
- Agent Jonathan P. O'Brien
- Main IPC: A61K31/36
- IPC: A61K31/36 ; C07D405/12
Abstract:
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Public/Granted literature
- US20090131492A1 Indole derivatives as CFTR modulators Public/Granted day:2009-05-21
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