Invention Grant
- Patent Title: Methods for producing optically active alcohols
- Patent Title (中): 光学活性醇的制造方法
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Application No.: US11151764Application Date: 2005-06-13
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Publication No.: US07645599B2Publication Date: 2010-01-12
- Inventor: Hiroaki Yamamoto , Momoko Ueda , Ritsuzui Pan , Takeshi Hamatani
- Applicant: Hiroaki Yamamoto , Momoko Ueda , Ritsuzui Pan , Takeshi Hamatani
- Applicant Address: JP Osaka
- Assignee: Daicel Chemical Industries, Ltd.
- Current Assignee: Daicel Chemical Industries, Ltd.
- Current Assignee Address: JP Osaka
- Agency: Lahive & Cockfield, LLP
- Agent Jeanne M. DiGiorgi, Esq.; Maneesh Gulati, Esq.
- Priority: JP2001-375041 20011207; JP2002-152955 20020527
- Main IPC: C12N7/02
- IPC: C12N7/02 ; C12N9/04 ; C12Q1/00 ; C12Q1/68 ; C12N1/20 ; C12N15/00 ; C07H21/04 ; C12Q21/04 ; C12Q1/32
Abstract:
A method for producing optically active alcohols is provided. Optically active alcohols are useful intermediates in pharmaceutical production. The method of the present invention enables simple and efficient production of optically active alcohols with a high optical purity. According to the production method disclosed, optically active alcohols are produced via asymmetric reduction of 3-quinuclidinone using tropinone reductase-I. For example, the use of tropinone reductase-I derived from plants like Datura stramonium and Hyoscyamus niger allows the production of high optical purity (R)-3-quinuclidinol.
Public/Granted literature
- US20050227336A1 Methods for producing optically active alcohols Public/Granted day:2005-10-13
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