A rapid search system and method in high capacity hard disk drive clusters includes: designating a specific hard disk drive as a destination hard disk drive with a predetermined purpose using hard disk drive location codes provided in a hard disk device code database, and then finding the destination hard disk drive according to the hard disk drive cabinet code, the hard disk drive drawer code and the hard disk drive code of the specific hard disk drive, whereby communicating with the destination hard disk drive. It does not use broadcast packets to find the destination hard disk drive, and therefore can avoid broadcast storm and system breakdown.