Systems and methods for performing large-radix numeric operations. A first number may be segmented into large-radix segments, wherein numbers of the segments are generated such that radix of the segment is greater than radix of the first number. As a result, a plurality of disparate processor-based computing systems may be configured to perform various numeric operations on the large-radix segments of the number and output results of a numeric operation as a number whose radix is equal to the radix of the first number.